Beyond Neoantigens: Optimizing Antigen Cassette Design for Enhanced Vaccine Efficacy

Time: 2:00 pm
day: Pre-Conference Focus Day


  • The Ancer® neoantigen discovery platform identifies high-quality effector neoantigens, filters out inhibitory sequences, and generates string-of-beads designs for oligonucleotide-based cancer vaccines
  • Neoantigen cassette design is a non-trivial exercise, with parameters such as number of neoantigens, ordering, and inclusion of trafficking signals having a significant impact on mRNA vaccine immunogenicity and efficacy